Study Reveals How Human Cells Detect Temperature Changes
A new study has identified a previously unknown mechanism by which human cells sense temperature, offering insights into how the body distinguishes between normal warmth and potentially harmful heat.

Researchers from Northwestern University, US, found that a sensor protein called TRPM3, located in the cell membrane—the outer protective layer of the cell—plays a crucial role in detecting environmental heat.

When exposed to higher temperatures, TRPM3 allows charged particles (ions) to flow into the cell, generating nerve signals that are transmitted to the brain. These signals are then interpreted as sensations of heat or pain, the researchers explained.

The findings could have significant implications for understanding pain perception and developing new therapies for temperature-related or chronic pain disorders, the team said.

The study adds to growing research on how the human body’s sensory systems maintain balance between comfort and danger when exposed to varying temperatures.